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Journal of Applied Physics / Volume 107 / Issue 11 / ARTICLES / Applied Biophysics

J. Appl. Phys. 107, 114701 (2010); http://dx.doi.org/10.1063/1.3432757 (9 pages)

Modeling the performance of magnetic nanoparticles in multimodal cancer therapy

S. Purushotham and R. V. Ramanujan

School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798

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(Received 11 March 2010; accepted 26 April 2010; published online 3 June 2010)

Composite magnetic nanoparticles (MNPs) consisting of an MNP core and drug loaded polymer shell can increase the efficacy of cancer therapy by overcoming several limitations of conventional hyperthermia and chemotherapy. Multimodal therapy consisting of simultaneous hyperthermia and chemotherapy can increase therapeutic efficiency compared to individual applications of these modalities. Factors influencing power output in an alternating magnetic field (AMF) for superparamagnetic γ-Fe2O3 and Fe3O4 iron oxide MNP were studied. The optimum MNP properties for in vivo magnetic hyperthermia were identified. For a 375 kHz AMF, 23 nm γ-Fe2O3 MNP and 12 nm Fe3O4 MNP produce maximum heating, heat generation is dependent primarily on Néel relaxation and is insensitive to polymer shell thickness. The heating of tumors by uniformly distributed magnetic clusters of optimized iron oxide MNP was modeled. The MNP mass required to heat tumors to hyperthermia temperatures was calculated, the Fe3O4 MNP concentration in the tumor required for hyperthermia was in the range of 0.12–2.2 g ml−1 for Fe3O4 and 0.06–1.7 g ml−1 for γ-Fe2O3 MNP respectively. In vitro drug release from doxorubicin loaded poly-n-isopropylacrylamide coated MNP was also modeled to understand the influence of shell thickness on thermoresponsive drug release. An increase in shell thickness or decrease in temperature resulted in decreased drug release rates. The MNP mass requirements for hyperthermia closely match the requirements for chemotherapy confirming the feasibility of these particles for combined hyperthermia and drug release applications.

© 2010 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. METHODOLOGY
    1. Power output from MNPs exposed to an AMF
    2. Modeling of tumor heating from optimized iron oxide nanoparticles
    3. Modeling of drug release from doxorubicin loaded PNIPAM—iron oxide CNPs
  3. RESULTS AND DISCUSSION
    1. Power generation from MNPs in an AMF
    2. Tumor heating by iron oxide MNPs
    3. Dox release from polymer—iron oxide CNPs
  4. CONCLUSIONS

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KEYWORDS and PACS

Keywords

biomedical materials, drugs, hyperthermia, nanobiotechnology, patient treatment, tumours

PACS

  • 87.85.Rs

    Nanotechnologies-applications

  • 87.19.Pp

    Biothermics and thermal processes in biology

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3432757

PUBLICATION DATA

ISSN

0021-8979 (print)  
1089-7550 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    C. A. Sawyer, A. H. Habib, K. Miller, K. N. Collier, C. L. Ondeck, and M. E. McHenry, J. Appl. Phys. 105, 07B320 (2009)JAPIAU00010500000707B320000001.

    A. H. Habib, C. L. Ondeck, P. Chaudhary, M. R. Bockstaller, and M. E. McHenry, J. Appl. Phys. 103, 07A307(2008)JAPIAU00010300000707A307000001.


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