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Journal of Applied Physics / Volume 105 / Issue 8 / APPLIED BIOPHYSICS

J. Appl. Phys. 105, 084703 (2009); http://dx.doi.org/10.1063/1.3100210 (6 pages)

Topological change and impedance spectrum of rat olfactory receptor I7: A comparative analysis with bovine rhodopsin and bacteriorhodopsin

Eleonora Alfinito, Cecilia Pennetta, and Lino Reggiani

Dipartimento di Ingegneria dell’Innovazione, Università del Salento, 73100 Lecce, Italy, EU and Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia (CNISM), via della Vasca Navale 84, 00146 Roma, Italy, EU

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(Received 30 June 2008; accepted 16 February 2009; published online 29 April 2009)

We present a theoretical investigation on possible selection of olfactory receptors (ORs) as sensing components of nanobiosensors. Accordingly, we generate the impedance spectra of the rat OR I7 in the native and activated states and analyze their differences. In this way, we connect the protein morphological transformation, caused by the sensing action, with its change in electrical impedance. The results are compared with those obtained by studying the best known protein of the G protein coupled receptor (GPCR) family: bovine rhodopsin. Our investigations indicate that a change in morphology goes with a change in impedance spectrum mostly associated with a decrease in the static impedance up to about 60% of the initial value, in qualitative agreement with existing experiments on rat OR I7. The predictiveness of the model is tested successfully for the case of recent experiments on bacteriorhodopsin. The present results point to a promising development of a new class of nanobiosensors based on the electrical properties of GPCR and other sensing proteins.

© 2009 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. THEORY
    1. Materials and methods
  3. RESULTS AND DISCUSSION
    1. Global properties
  4. A FURTHER TEST OF THE NETWORK MODEL
  5. CONCLUSIONS

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KEYWORDS and PACS

Keywords

bioelectric phenomena, bioMEMS, biosensors, chemioception, electric impedance, microsensors, molecular configurations, nanoelectromechanical devices, proteomics

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3100210

PUBLICATION DATA

ISSN

0021-8979 (print)  
1089-7550 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
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