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Journal of Applied Physics / Volume 105 / Issue 8 / APPLIED BIOPHYSICS

J. Appl. Phys. 105, 084702 (2009); http://dx.doi.org/10.1063/1.3095761 (6 pages)

Modeling of colloidal transport in capillaries

G. Stober1, L. J. Steinbock1, and U. F. Keyser1,2

1Institute for Experimental Physics I (MOP), University Leipzig, Linnéstrasse 5, 04103 Leipzig, Germany
2Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, United Kingdom

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(Received 15 September 2008; accepted 6 February 2009; published online 27 April 2009)

We dynamically model the full ionic current signature of micron-sized colloids passing through microcapillaries in silico for the first time. Our novel computer simulation allows free adjustment of all relevant experimental parameters such as the geometry of the used orifice, noise sources, external applied pressure or voltage, and the charge of the particles passing through the channel. We demonstrate that our algorithm correctly describes the experimentally observed signals in our recently introduced microcapillary based Coulter counters. Finally, we quantitatively investigate the influence of DNA-functionalized particles on the signal amplitude as a function of salt concentration and particle size.

© 2009 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. EXPERIMENTS
  3. DYNAMIC MODEL
  4. MODEL GEOMETRY
  5. ELECTROSTATIC DESCRIPTION
  6. SIMULATION OF TRANSLOCATIONS
  7. DNA COATED COLLOIDS
  8. CONCLUSION

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KEYWORDS and PACS

Keywords

biochemistry, capillarity, colloids, DNA, molecular biophysics, particle size

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3095761

PUBLICATION DATA

ISSN

0021-8979 (print)  
1089-7550 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
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    O. Otto, C. Gutsche, F. Kremer, and U. F. Keyser, Rev. Sci. Instrum. 79, 023710 (2008)RSINAK000079000002023710000001.

    N. A. Mortensen, F. Okkels, and H. Bruus, Phys. Rev. E 71, 057301 (2005).


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